Fig. 1. Acid sphingomyelinase-deficient C57BL/6 develop ameliorated adoptively transferred EAE. Acid sphingomyelinase-deficient mice and C57BL/6 wildtype littermates received 3x10⁶ cells encephalitogenic T cells intraperitoneally. Mice were weighed and scored twice daily. Shown is the clinical course of a transfer EAE experiment (a) and the number of diseased mice in all groups (b). Shown are means ± SD, n= 8 for wildtype T cells in wildtype recipients (red line), n= 11 for acid sphingomyelinase deficient T cells in wildtype recipients (black line) and n= 6 for wildtype T cells in acid sphingomyelinase deficient recipients (blue line).